J3374 — Injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg
J3374 is a HCPCS Level II code for injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
Medically Unlikely Edits — units per day
The most units of J3374 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 600 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- outpatient
- 600 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- DME supplier
- 600 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for J3374
- Long descriptor
- Injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg
- Short descriptor
- Inj, vancomycin (mylan) 10mg
- Added
- July 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J3374
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J3374 is not quite right, the correct code is very often within a few positions of it.
- J3358Ustekinumab, for intravenous injection, 1 mg
- J3360Injection, diazepam, up to 5 mg
- J3364Injection, urokinase, 5000 iu vialterminated
- J3365Injection, iv, urokinase, 250,000 i.u. vialterminated
- J3370Injection, vancomycin hcl, 500 mgterminated
- J3371Injection, vancomycin hcl (mylan), not therapeutically equivalent to j3370, 500 mgterminated
- J3372Injection, vancomycin hcl (xellia), not therapeutically equivalent to j3370, 500 mgterminated
- J3373Injection, vancomycin hydrochloride, 10 mg
- J3375Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg
- J3376Injection, vancomycin hcl (hikma), not therapeutically equivalent to j3373, 10 mg
- J3379Injection, valproate sodium, 5 mg
- J3380Injection, vedolizumab, intravenous, 1 mg
- J3385Injection, velaglucerase alfa, 100 units
- J3386Injection, etuvetidigene autotemcel, per treatment
- J3387Injection, elivaldogene autotemcel, per treatment
- J3389Topical administration, prademagene zamikeracel, per treatment
Questions about J3374
What is HCPCS code J3374?
J3374 is a HCPCS Level II code for injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J3374?
The CMS HCPCS file marks J3374 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
How is J3374 paid under the physician fee schedule?
J3374 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).