J2281 — Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg
J2281 is a HCPCS Level II code for injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
Medically Unlikely Edits — units per day
The most units of J2281 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 4 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- outpatient
- 4 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- DME supplier
- 4 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for J2281
- Long descriptor
- Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg
- Short descriptor
- Inj moxifloxacin (fres kabi)
- Added
- January 1, 2023
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J2281
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J2281 is not quite right, the correct code is very often within a few positions of it.
- J2270Injection, morphine sulfate, up to 10 mg
- J2271Injection, morphine sulfate, 100mgterminated
- J2272Injection, morphine sulfate (fresenius kabi), not therapeutically equivalent to j2270, up to 10 mg
- J2274Injection, morphine sulfate, preservative-free for epidural or intrathecal use, 10 mg
- J2275Injection, morphine sulfate (preservative-free sterile solution), per 10 mgterminated
- J2277Injection, motixafortide, 0.25 mg
- J2278Injection, ziconotide, 1 microgram
- J2280Injection, moxifloxacin, 100 mg
- J2290Injection, nafcillin sodium, 20 mg
- J2291Injection, nafcillin sodium (baxter), 20 mg
- J2300Injection, nalbuphine hydrochloride, per 10 mg
- J2305Injection, nitroglycerin, 5 mg
- J2310Injection, naloxone hydrochloride, per 1 mgterminated
- J2311Injection, naloxone hydrochloride (zimhi), 1 mgterminated
- J2312Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
- J2313Injection, naloxone hydrochloride (zimhi), 0.01 mg
Questions about J2281
What is HCPCS code J2281?
J2281 is a HCPCS Level II code for injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J2281?
The CMS HCPCS file marks J2281 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is J2281 paid under the physician fee schedule?
J2281 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).