E2101 — Blood glucose monitor with integrated lancing/blood sample
E2101 is a HCPCS Level II code for blood glucose monitor with integrated lancing/blood sample. It belongs to the Durable Medical Equipment section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Medically Unlikely Edits — units per day
The most units of E2101 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 0 — never payable MAI 3 — Date of Service Edit: Clinical · CMS Policy
- outpatient
- 0 — never payable MAI 3 — Date of Service Edit: Clinical · CMS Policy
- DME supplier
- 1 unit MAI 2 — Date of Service Edit: Policy · Code Descriptor / CPT Instruction
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for E2101
- Long descriptor
- Blood glucose monitor with integrated lancing/blood sample
- Short descriptor
- Bld glucose monitor w lance
- Added
- January 1, 2002
- BETOS
- D1E
- Pricing indicator
- 32 — DMEPOS
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Inexpensive and routinely purchased DME. Price subject to floors and ceilings.
Codes adjacent to E2101
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If E2101 is not quite right, the correct code is very often within a few positions of it.
- E1832Static progressive stretch finger device, extension and/or flexion, with or without range of motion adjustment, includes all components and accessories
- E1840Dynamic adjustable shoulder flexion / abduction / rotation device, includes soft interface material
- E1841Static progressive stretch/patient actualized serial stretch shoulder device, with or without range of motion adjustment, includes all components and accessories
- E1902Communication board, non-electronic augmentative or alternative communication device
- E1905Virtual reality cognitive behavioral therapy device (cbt), including pre-programmed therapy software
- E2000Gastric suction pump, home model, portable or stationary, electric
- E2001Suction pump, home model, portable or stationary, electric, any type, for use with external urine and/or fecal management system
- E2100Blood glucose monitor with integrated voice synthesizer
- E2102Adjunctive, non-implanted continuous glucose monitor or receiver
- E2103Non-adjunctive, non-implanted continuous glucose monitor or receiver
- E2104Home blood glucose monitor for use with integrated lancing/blood sample testing cartridge
- E2120Pulse generator system for tympanic treatment of inner ear endolymphatic fluid
- E2201Manual wheelchair accessory, nonstandard seat frame, width greater than or equal to 20 inches and less than 24 inches
- E2202Manual wheelchair accessory, nonstandard seat frame width, 24-27 inches
- E2203Manual wheelchair accessory, nonstandard seat frame depth, 20 to less than 22 inches
- E2204Manual wheelchair accessory, nonstandard seat frame depth, 22 to 25 inches
Questions about E2101
What is HCPCS code E2101?
E2101 is a HCPCS Level II code for blood glucose monitor with integrated lancing/blood sample. It sits in the Durable Medical Equipment section.
Does Medicare cover E2101?
The CMS HCPCS file marks E2101 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.