C9310 — Injection, leucovorin calcium (avyxa), 1 mg
C9310 is a HCPCS Level II code for injection, leucovorin calcium (avyxa), 1 mg. It belongs to the Outpatient Prospective Payment System section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for C9310
- Long descriptor
- Injection, leucovorin calcium (avyxa), 1 mg
- Short descriptor
- Inj, leucovorin cal (avyxa)
- Added
- July 1, 2026
- BETOS
- O1E
- Pricing indicator
- 53 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Statute.
Codes adjacent to C9310
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If C9310 is not quite right, the correct code is very often within a few positions of it.
- C9302Injection, zanidatamab-hrii, 2 mgterminated
- C9303Injection, zolbetuximab-clzb, 1 mgterminated
- C9304Injection, marstacimab-hncq, 0.5 mgterminated
- C9305Injection, nipocalimab-aahu, 3 mgterminated
- C9306Injection, telisotuzumab vedotin-tllv, 1 mgterminated
- C9307Injection, linvoseltamab-gcpt, 1 mgterminated
- C9308Injection, carboplatin (avyxa), 1 mgterminated
- C9309Injection, onasemnogene abeparvovec-brve, per treatmentterminated
- C9349Puraply, and puraply antimicrobial, any type, per square centimeterterminated
- C9352Microporous collagen implantable tube (neuragen nerve guide), per centimeter length
- C9353Microporous collagen implantable slit tube (neurawrap nerve protector), per centimeter length
- C9354Acellular pericardial tissue matrix of non-human origin (veritas), per square centimeter
- C9355Collagen nerve cuff (neuromatrix), per 0.5 centimeter length
- C9356Tendon, porous matrix of cross-linked collagen and glycosaminoglycan matrix (tenoglide tendon protector sheet), per square centimeter
- C9358Dermal substitute, native, non-denatured collagen, fetal bovine origin (surgimend collagen matrix), per 0.5 square centimeters
- C9359Porous purified collagen matrix bone void filler (integra mozaik osteoconductive scaffold putty, integra os osteoconductive scaffold putty), per 0.5 cc
Questions about C9310
What is HCPCS code C9310?
C9310 is a HCPCS Level II code for injection, leucovorin calcium (avyxa), 1 mg. It sits in the Outpatient Prospective Payment System section.
Does Medicare cover C9310?
The CMS HCPCS file marks C9310 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.