B4105 — In-line cartridge containing digestive enzyme(s) for enteral feeding, each
B4105 is a HCPCS Level II code for in-line cartridge containing digestive enzyme(s) for enteral feeding, each. It belongs to the Enteral and Parenteral Therapy section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for B4105
- Long descriptor
- In-line cartridge containing digestive enzyme(s) for enteral feeding, each
- Short descriptor
- Enzyme cartridge enteral nut
- Added
- January 1, 2019
- BETOS
- O1C
- Pricing indicator
- 39 — DMEPOS
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Parenteral and enteral nutrition.
Codes adjacent to B4105
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If B4105 is not quite right, the correct code is very often within a few positions of it.
- B4082Nasogastric tubing without stylet
- B4083Stomach tube - levine type
- B4087Gastrostomy/jejunostomy tube, standard, any material, any type, each
- B4088Gastrostomy/jejunostomy tube, low-profile, any material, any type, each
- B4100Food thickener, administered orally, per ounce
- B4102Enteral formula, for adults, used to replace fluids and electrolytes (e.g., clear liquids), 500 ml = 1 unit
- B4103Enteral formula, for pediatrics, used to replace fluids and electrolytes (e.g., clear liquids), 500 ml = 1 unit
- B4104Additive for enteral formula (e.g., fiber)
- B4148Enteral feeding supply kit; elastomeric control fed, per day, includes but not limited to feeding/flushing syringe, administration set tubing, dressings, tape
- B4149Enteral formula, manufactured blenderized natural foods with intact nutrients, includes proteins, fats, carbohydrates, vitamins and minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
- B4150Enteral formula, nutritionally complete with intact nutrients, includes proteins, fats, carbohydrates, vitamins and minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
- B4152Enteral formula, nutritionally complete, calorically dense (equal to or greater than 1.5 kcal/ml) with intact nutrients, includes proteins, fats, carbohydrates, vitamins and minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
- B4153Enteral formula, nutritionally complete, hydrolyzed proteins (amino acids and peptide chain), includes fats, carbohydrates, vitamins and minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
- B4154Enteral formula, nutritionally complete, for special metabolic needs, excludes inherited disease of metabolism, includes altered composition of proteins, fats, carbohydrates, vitamins and/or minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
- B4155Enteral formula, nutritionally incomplete/modular nutrients, includes specific nutrients, carbohydrates (e.g., glucose polymers), proteins/amino acids (e.g., glutamine, arginine), fat (e.g., medium chain triglycerides) or combination, administered through an enteral feeding tube, 100 calories = 1 unit
- B4157Enteral formula, nutritionally complete, for special metabolic needs for inherited disease of metabolism, includes proteins, fats, carbohydrates, vitamins and minerals, may include fiber, administered through an enteral feeding tube, 100 calories = 1 unit
Questions about B4105
What is HCPCS code B4105?
B4105 is a HCPCS Level II code for in-line cartridge containing digestive enzyme(s) for enteral feeding, each. It sits in the Enteral and Parenteral Therapy section.
Does Medicare cover B4105?
The CMS HCPCS file marks B4105 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.