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E34.321

E34.321Primary insulin-like growth factor-1 (IGF-1) deficiency

Billable / specific codeICD-10-CM

E34.321 is a billable, specific ICD-10-CM code for primary insulin-like growth factor-1 (igf-1) deficiency. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Acid-labile subunit gene (IGFALS) defect
  • Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
  • Growth hormone insensitivity syndrome (GHIS)
  • Insulin-like growth factor 1 gene (IGF1) defect
  • Laron type short stature
  • Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
  • Signal transducer and activator of transcription 5B gene (STAT5b) defect

Risk adjustment

E34.321 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E34.321 is named in 1 Medicare coverage policy 1 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A57204Billing and Coding: MRI and CT Scans of the Head and Neck

How E34.321 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E34.321.

  • DwarfismLaron-type
  • Short, shortening, shortnessstature NECLaron-type
  • Short, shortening, shortnessstature NECdue togenetic causesacid-labile subunit gene defect(IGFALS)
  • Short, shortening, shortnessstature NECdue togenetic causesgrowth hormone gene 1 defect with growth hormone neutralizing antibodies(GH1)
  • Short, shortening, shortnessstature NECdue togenetic causesgrowth hormone insensitivity syndrome(GHIS)
  • Short, shortening, shortnessstature NECdue togenetic causesinsulin-like growth factor 1 gene defect(IGF1)
  • Short, shortening, shortnessstature NECdue togenetic causesprimary insulin-like growth factor-1 deficiency(IGF-1)
  • Short, shortening, shortnessstature NECdue togenetic causessevere primary insulin-like growth factor-1 deficiency(SPIGFD)
  • Short, shortening, shortnessstature NECdue togenetic causessignal transducer and activator of transcription 5B gene defect(STAT5b)

Related codes at this level

Codes that share E34.32. If E34.321 is not quite right, the correct code is usually one of these.

Questions about E34.321

Is E34.321 a billable ICD-10-CM code?
Yes. E34.321 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E34.321 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Disorders of other endocrine glands (E20-E35).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.