MCMedicalCodingSoftware
E34.321

E34.321: Primary insulin-like growth factor-1 (IGF-1) deficiency

Billable / specific codeICD-10-CM

E34.321 is a billable, specific ICD-10-CM code for primary insulin-like growth factor-1 (igf-1) deficiency. It is valid for submission on a claim.

Check E34.321 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Acid-labile subunit gene (IGFALS) defect
  • Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
  • Growth hormone insensitivity syndrome (GHIS)
  • Insulin-like growth factor 1 gene (IGF1) defect
  • Laron type short stature
  • Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
  • Signal transducer and activator of transcription 5B gene (STAT5b) defect

Excludes1 inherited from the categories above E34.321

A category’s note binds every code beneath it.

Written on E34.3: Short stature due to endocrine disorder

  • achondroplastic short stature (Q77.4)
  • hypochondroplastic short stature (Q77.4)
  • nutritional short stature (E45)
  • pituitary short stature (E23.0)
  • progeria (E34.8)
  • renal short stature (N25.0)
  • Russell-Silver syndrome (Q87.19)
  • short-limbed stature with immunodeficiency (D82.2)
  • short stature (child) (R62.52)
  • short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
  • short stature NOS (R62.52)

Written on E34: Other endocrine disorders

  • pseudohypoparathyroidism (E20.1)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E34.321 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A57204Billing and Coding: MRI and CT Scans of the Head and Neck

Alphabetic index entries that lead here

  • Dwarfism›Laron-type
  • Short, shortening, shortness›stature NEC›Laron-type
  • Short, shortening, shortness›stature NEC›due to›genetic causes›acid-labile subunit gene defect(IGFALS)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›growth hormone gene 1 defect with growth hormone neutralizing antibodies(GH1)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›growth hormone insensitivity syndrome(GHIS)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›insulin-like growth factor 1 gene defect(IGF1)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›primary insulin-like growth factor-1 deficiency(IGF-1)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›severe primary insulin-like growth factor-1 deficiency(SPIGFD)
  • Short, shortening, shortness›stature NEC›due to›genetic causes›signal transducer and activator of transcription 5B gene defect(STAT5b)

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E34.32

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.