S3866 — Genetic analysis for a specific gene mutation for hypertrophic cardiomyopathy (hcm) in an individual with a known hcm mutation in the family
S3866 is a HCPCS Level II code for genetic analysis for a specific gene mutation for hypertrophic cardiomyopathy (hcm) in an individual with a known hcm mutation in the family. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S3866
- Long descriptor
- Genetic analysis for a specific gene mutation for hypertrophic cardiomyopathy (hcm) in an individual with a known hcm mutation in the family
- Short descriptor
- Spec gene test hyp cardiomy
- Added
- April 1, 2009
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S3866
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S3866 is not quite right, the correct code is very often within a few positions of it.
- S3849Genetic testing for niemann-pick disease
- S3850Genetic testing for sickle cell anemia
- S3852Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease
- S3853Genetic testing for myotonic muscular dystrophy
- S3854Gene expression profiling panel for use in the management of breast cancer treatment
- S3855Genetic testing for detection of mutations in the presenilin - 1 geneterminated
- S3861Genetic testing, sodium channel, voltage-gated, type v, alpha subunit (scn5a) and variants for suspected brugada syndrome
- S3865Comprehensive gene sequence analysis for hypertrophic cardiomyopathy
- S3870Comparative genomic hybridization (cgh) microarray testing for developmental delay, autism spectrum disorder and/or intellectual disability
- S3890Dna analysis, fecal, for colorectal cancer screeningterminated
- S3900Surface electromyography (emg)
- S3902Ballistocardiogram
- S3904Masters two step
- S4005Interim labor facility global (labor occurring but not resulting in delivery)
- S4011In vitro fertilization; including but not limited to identification and incubation of mature oocytes, fertilization with sperm, incubation of embryo(s), and subsequent visualization for determination of development
- S4013Complete cycle, gamete intrafallopian transfer (gift), case rate
Questions about S3866
What is HCPCS code S3866?
S3866 is a HCPCS Level II code for genetic analysis for a specific gene mutation for hypertrophic cardiomyopathy (hcm) in an individual with a known hcm mutation in the family. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S3866?
The CMS HCPCS file marks S3866 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S3866 paid under the physician fee schedule?
S3866 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.